CMB is a 501(c)(3) organization that was founded in 2006 to transform the way high school students experience scientific discovery. To achieve this ambitious goal, the Integrative Biosciences Program has leveraged the collective expertise of research scientists, education researchers, in-service science teachers, teacher educators, nationally recognized evaluators, bioinformaticians and data specialists, and science media and communication experts. Our research-based programs for teachers and students conform to a core set of design principals that provide students with early exposure to the scientific model-building enterprise, early immersion in interdisciplinary learning experiences, and early opportunities to explore science as a collaborative social enterprise.